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KMID : 0624620180510120648
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BMB Reports
2018 Volume.51 No. 12 p.648 ~ p.653
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SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
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Xu Liyun
Lu Changchang
Huang Yanyan
Zhou Jihang
Wang Xincheng
Liu Chaowu
Chen Jun
Le Hanbo
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Abstract
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Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor for poor survival. Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12.
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KEYWORD
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Biomarker, Cell growth, Lung adenocarcinoma, Metastasis, SPINK1
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